Exam objectives for Physiology

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Examination of the problem of Physiology. 184 tasks.

Physiology of excitable tissues

1. It is known that ion channels of excitable membranes reguli¬ruyut cell membrane potentials amplitude. Experimentally obnaru¬zheno the poison tetrodotoxin blocks sodium channels of excitable cell membrane.
Questions: 1. How will the potential of the rest of excitability of the cells? 2. How will the potential of action excitable klet¬ki? 3. As with a different distribution of ions on the outside and VNU-friction side of the cell membrane? 4. Will tetrodotoksii on conduction of excitation along the nerve fiber?

2. It is known that the phase of the action potential of nerve fibers (fast depolarization and repolarization) occur due to movement of sodium and potassium ions along a concentration gradient. In the experiments on the nerve acted ouabain - a substance inhibits the activity of ATPase and then spent a long rhythmic stimulation of the nerve.
Questions: 1. As with a different distribution of ions on the outside and vnu¬trenney side of the cell membrane? 2. Will the value of the resting potential and potential in the processed dey¬stviya ouabain nerve fiber?

3. It is known that the sodium concentration gradient between the two sides of the cell membrane potential influences the value of the action rest and excitable cells. In the experiment, increased concentration of sodium ions inside nerve cells initially very slightly, then leveled the sodium ion concentration within cells and in the medium surrounding the cell.
Q: How will the value of rest and action potentials in the two described situations?

4. It is known that the drug etilendiamintetraamony (EDTA) svya¬zyvaet in living tissues calcium ions. In the experimental conditions on the neuromuscular preparation frog to the neuromuscular synapse entered EDTA.
Questions: 1. How is the process of excitation of the synapse? 2. How will the EDTA in the synthesis of acetylcholine, the permeability of the presynaptic membrane of the mediator, the generation of postsynaptic potential and cholinesterase activity?

5. It is known that the conduction of excitation in the synapse includes ne¬skolkih stages. In the experiment, the impact of the chemical on the neuromuscular synapses led to interrupting transmission of excitation from the nerve to the skeletal muscle. When introduced into the specified region atsetil¬holina conduction of excitation across the synapse is not restored. The introduction of the enzyme acetylcholinesterase restored conduction of excitation.
Questions: 1. List the possible mechanisms of the termination of the excitation of the synapse? 2. What is the mechanism of action of the substance being studied in the nerve synapse my¬shechny?
and so and so.


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